Complications of Ozempic (semaglutide)

Semaglutide is a revolutionary drug. But what about its long-term effects? Is Ozempic safe to use for several months or years?

The truth is, as the drug is relatively new, the long-term effects of Ozempic are not yet fully known.

Ozempic (semaglutide) was originally designed to control blood sugar levels in type 2 diabetes patients. But it’s also prescribed (off-label) for weight loss in people with overweight or obesity.

Ozempic is generally considered safe. Even though the complications below are uncommon – and the benefits of Ozempic often outweigh the risks for most people – it’s important to be aware of them.

How Ozempic works

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs work by mimicking GLP-1, a hormone naturally produced in the intestines.

GLP-1 stimulates insulin production and helps regulate blood glucose levels. It’s also associated with appetite suppression and increased feelings of fullness, which leads to reduced food intake and weight loss.

Complications of Ozempic

Ozempic (semaglutide) can have complications, including:
  • Pancreatitis
  • Acute kidney injury
  • Gallbladder problems
  • Diabetic retinopathy (worsening of, in someone with diabetes)
  • Tachycardia (increased heart rate)
  • Thyroid cancer
  • Vision problems
  • Mental health issues.
Whilst most side effects are short-term and go away when you stop taking the medication, some long-term effects can last for months or years.