Complications of Ozempic (semaglutide)

Semaglutide is a revolutionary drug. But what about its long-term effects? Is Ozempic safe to use for several months or years?

The truth is, as the drug is relatively new, the long-term effects of Ozempic are not yet fully known.

Ozempic (semaglutide) was originally designed to control blood sugar levels in type 2 diabetes patients. But it’s also prescribed (off-label) for weight loss in people with overweight or obesity.

Ozempic is generally considered safe. Even though the complications below are uncommon – and the benefits of Ozempic often outweigh the risks for most people – it’s important to be aware of them.

How Ozempic works

Semaglutide belongs to a class of medications known as glucagon-like peptide-1 (GLP-1) receptor agonists. These drugs work by mimicking GLP-1, a hormone naturally produced in the intestines.

GLP-1 stimulates insulin production and helps regulate blood glucose levels. It’s also associated with appetite suppression and increased feelings of fullness; which leads to reduced food intake and weight loss.

Complications of Ozempic

Ozempic (semaglutide) can have complications, including:
  • Pancreatitis
  • Acute kidney injury
  • Gallbladder problems
  • Diabetic retinopathy (worsening of, in someone with diabetes)
  • Tachycardia (increased heart rate)
  • Thyroid cancer
  • Vision problems
  • Mental health issues.
Whilst most side effects are short-term and go away when you stop taking the medication, some long-term effects can last for months or years.