How to stop antidepressants

The key is to taper off the medication gradually to minimise withdrawal symptoms.


Tapering off antidepressants

The NHS recommends that patients should not stop taking antidepressants suddenly. Instead, the dose should be slowly reduced over several weeks or months, depending on the type of antidepressant, dosage, and treatment duration.

Common types of antidepressants

The most common type of antidepressant are SSRIs and SNRIs.

Selective serotonin reuptake inhibitors (SSRIs)

SSRIs are the most commonly prescribed type of antidepressants. They cause fewer side effects than some of the others. They are also less likely to cause a serious overdose.

Examples of SSRIs include:

  • Citalopram
  • Paroxetine
  • Sertraline
  • Escitalopram
  • Fluoxetine.

Serotonin-noradrenaline reuptake inhibitors (SNRIs)

SNRIs work in a similar way to SSRIs. Some people respond better to SNRIs than to SSRIs.

Examples of SNRIs include:

  • Duloxetine
  • Venlafaxine.

So. How do you stop antidepressants?

Here’s a general outline for tapering off antidepressants:
  • Standard treatment (6-8 months): Taper off over 6-8 weeks
  • Maintenance therapy: Taper off more gradually, reducing the dose by 1/4 every 4-6 weeks
  • Short-term treatment (less than 8 weeks): Discontinue over 1-2 weeks.

What happens if you withdraw them too quickly? Withdrawal symptoms can occur.

Withdrawal symptoms

If you stop taking antidepressants too quickly you may experience unpleasant withdrawal symptoms. These symptoms can include:
  • Insomnia
  • Irritability
  • Stomach issues
  • Headaches
  • Restlessness
  • Sweating
  • Lower mood or increased anxiety.

If withdrawal symptoms occur, consider slowing down the tapering process or reintroducing the original antidepressant at a lower dose.

Additional Guidance

For specific guidance on switching or discontinuing antidepressants, consult the Maudsley Prescribing Guidelines or NICE guidelines.

Additionally, the British National Formulary (BNF) provides information on the withdrawal effects of specific antidepressants