What are uterine fibroids?

Definition

  • Uterine fibroids, also known as uterine leiomyomas, are benign (non-cancerous) growths that develop in the uterus.
  • They are made up of muscle and fibrous tissue and can vary in size, shape, and location – they may be tiny or as big as a football.
  • Natural history: they often regress (go away) with no treatment, e.g. after a pregnancy or menopause. This facts affects many treatment decisions.

Epidemiology (who gets them)

  • Fibroids are very, very common – affecting 70-80% women over 50 years (and Black women have an increased risk)
  • And (normal variant) heavy periods are so common, there is huge overlap; and confusion on whether the fibroids are causing the patients symptoms
  • The high prevalence means fibroids in most women are actually normal, not a disease, and usually don’t cause symptoms.

Types

  • Intramural: Grow within the muscular wall of the uterus.
  • Subserosal: Grow on the outside of the uterus.
  • Submucosal: Grow just beneath the uterine lining.
  • Pedunculated: Grow on a stalk-like structure.

Different types of uterine fibroids and their locationsDifferent types of fibroid

Symptoms:
  • Heavy or prolonged menstrual periods (commonest presentation).
  • Low abdominal or pelvic pain or pressure.
  • Frequent urination or constipation.
  • Infertility or miscarriage.

Diagnosis

  • Ultrasound (or MRI in some).
  • Histopathological examination (biopsy) – sometimes.
  • None are 100% reliable.
Treatment options
  • Watchful waiting: Monitoring with regular check-ups.
  • Medication: Hormone therapy (e.g. GnRH agonists:  leuprorelin (brand name Lupron) and triptorelin (brand name Decapeptyl). and/or painkillers
  • Surgery: Removal of fibroids (myomectomy) or uterus (hysterectomy).
  • Uterine artery embolisation (UAE): X-ray treatment that blocks blood flow to fibroids.
  • MRI-guided focused ultrasound: Non-invasive heat treatment.