What controls blood sodium levels?

It is complicated (very). Essentially, the kidneys, heart/blood vessels, adrenal and pituitary glands work together to regulate sodium levels in the blood.

Kidneys 

  • Filter sodium from the blood and excrete it in urine
  • Retain sodium when blood sodium levels are low
  • Release water when sodium levels are high.

Heart and blood vessels 

  • Detect changes in sodium levels and blood volume
  • Stimulate the kidneys to increase sodium excretion when levels are too high.

Adrenal glands 

  • Secrete aldosterone when blood sodium levels are low
  • Aldosterone causes the kidneys to retain sodium and excrete potassium
  • Part of the renin, angiotensin, aldosterone (RAS) system
    • Works together to regulate sodium and potassium levels
    • Renin converts angiotensinogen to angiotensin I, which is then converted to angiotensin II
    • Angiotensin II narrows blood vessels, which raises blood pressure, and stimulates the release of aldosterone.

Pituitary gland

  • Sodium/water levels sensed by hypothalamus that stimulates pituitary gland
  • Antidiuretic hormone (ADH; or vasopressin) secreted by the pituitary gland when blood sodium levels are low
  • Causes the kidneys to conserve water.

Summary

We have described what controls blood sodium levels. Its complicated but we hope this has helped.